Table II.

Characteristics of Drug Release from Alginate Matrix Tablets Prepared with Different SAL/CG Ratios: 3:1 (F1), 2:1 (F2), 1:1 (F3), 1:1.5 (F4), 1:2 (F5), 1:3 (F6)

Formulation code	Amount of drug released (%) at 2 h (mean ± SD, n = 4)	t 50% (hour; mean ± SD, n = 4)	AUC (% mg h/ml) up to 2 h in acidic medium (mean ± SD, n = 4)	AUC (% mg h/ml) from 2 h to complete release in PB (mean ± SD, n = 4)
F1	68.35 ± 0.99	1.30 ± 0.03	77.29 ± 3.73	179.89 ± 4.26
F2	55.27 ± 0.95	1.72 ± 0.3	68.10 ± 1.70	379.36 ± 2.06
F3	53.22 ± 0.05	1.80 ± 0.02	66.26 ± 0.43	797.02 ± 0.95
F4	50.49 ± 0.52	1.95 ± 0.01	65.44 ± 0.09	917.07 ± 0.88
F5	51.71 ± 0.01	1.86 ± 0.01	64.18 ± 0.02	927.59 ± 0.84
F6	59.79 ± 0.075	1.53 ± 0.02	72.78 ± 0.15	343.19 ± 1.23
ANOVA test with F2 to F5	p < 0.05	p < 0.05	p < 0.05	p < 0.05

SAL Sodium Alginate; CG Calcium Gluconate; AUC Area Under the Curve