Table I.
Encapsulation Efficiency of Ofloxacin in Multilamellar and Revised-Phase Evaporation Liposomes
| Liposomal Lipid Composition | Molar Ratio | Liposomal Charge | MLVs Encapsulation Efficiency ± SD | REVs Encapsulation Efficiency ± SD |
|---|---|---|---|---|
| PC/CH | 4:1 | Neutral | 20.11 ± 0.54 | 13.15 ± 0.23 |
| PC/CH | 4:2 | Neutral | 39.13 ± 1.12 | 21.31 ± 0.45 |
| PC/CH | 4:3 | Neutral | 53.27 ± 0.67 | 35.72 ± 0.52 |
| PC/CH | 4:4 | Neutral | 47.35 ± 0.62 | 28.18 ± 0.28 |
| PC/CH/DP | 4:3:1 | Negative | 57.81 ± 0.49 | 36.61 ± 0.75 |
| PC/CH/SA | 4:3:1 | Positive | 59.01 ± 0.64 | 38.11 ± 0.83 |
| DPPC/CH | 4:1 | Neutral | 23.52 ± 0.13 | 16.13 ± 0.41 |
| DPPC/CH | 4:2 | Neutral | 38.17 ± 0.73 | 27.02 ± 0.72 |
| DPPC/CH | 4:3 | Neutral | 58.32 ± 0.51 | 43.53 ± 0.44 |
| DPPC/CH | 4:4 | Neutral | 49.15 ± 0.91 | 35.70 ± 0.56 |
| DPPC/CH/DP | 4:3:1 | Negative | 62.61 ± 0.86 | 45.21 ± 1.02 |
| DPPC/CH/SA | 4:3:1 | Positive | 65.50 ± 1.07 | 48.33 ± 0.82 |
Each value given in the table was calculated from n = 3 parallels and is given by the mean ± SD
PC egg phosphatidylcholine, CH cholesterol, DP dihexadecyl hydrogen phosphate, SA stearylamine, DPPC dipalmitoyl-l-α-phospatidylcholine