Fig. 8.

GFAP immunoreactive cells in primary CNS neoplasms. a High magnification image of a subependymal giant cell astrocytoma (SEGA) immunohistochemically stained for GFAP. Note variable staining intensity within tumor cells, including some that show uniform cytoplasmic staining. b High magnification image of a high-grade glioma (glioblastoma, WHO grade IV) immunohistochemically stained for GFAP. Note the variable staining of tumor cells as well as the pronounced nuclear and cytological atypia. Scale bars a, b 10 μm