Fig. 4.
Monte-Carlo simulation of stochastic self-assembly of RyR clusters using a simple growth model. The model yields cluster sizes and geometries which are very similar to those measured. (A) The simulation grid at the end of one simulation run (100 iterations) in which RyRs are shown schematically as circles. (Scale bar, 100 nm.) (B) The size distribution obtained from 1,000 runs. Inset: the same data on a log scale with a maximum-likelihood fit to an exponential distribution (red). The simulation parameters were (probabilities per pixel and iteration step): Pnucleation = 2.5 × 10−4, Pgrowth = 2.5 × 10−2 x Nneighbors, Pretention = 0.937.