Fig. 2.

Altered intestinal architecture and epithelial migration in Wsh and Mcpt4^−/− mice. (A) H&E stained jejunum from WT, Wsh, and Mcpt4^−/− mice was examined for (B) villus length, measured from villus-crypt junction to villus tip and (C) crypt depth, measured from crypt base to villus-crypt junction. (A) Arrows demonstrate approximate crypt measurements and highlight the difference between mice. (D) Epithelial migration was measured as the distance (μm) from crypt base to the farthest migrated BRDU⁺ cell. Values represent mean± SEM; n = 5–7 mice per group. Statistical significance is: (C) *, P < 0.01 and ***, P < 0.001 vs. WT; (D) **, P < 0.01 vs. WT.