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. 2009 Dec 16;106(52):22381–22386. doi: 10.1073/pnas.0906372106

Fig. 4.

Fig. 4.

Mast cell engraftment of Wsh mice with WT, but not Mcpt4−/− BMMCs restores basal intestinal permeability. Wsh mice were engrafted with BMMCs from WT or Mcpt4−/− mice. Twelve weeks later, jejunum was examined ex vivo for (A) TER and luminal-to-serosal flux of (B) FITC-dextran and (C) HRP. Values represent mean± SEM; n = 4–8 mice per group. Representative of three independent experiments. Statistical significance by two-way ANOVA is: (A) *, P < 0.05, ***, P < 0.001; (B) #, P < 0.01 WT control vs. Wsh control; **, P < 0.001 WT control vs. Wsh control, P < 0.05 WT control vs. Mcpt4−/− BMMC and P < 0.01 Wsh control vs. WT BMMC; (C) #, P < 0.05 WT control vs. Wsh control, WT control vs. KO BMMC, WT BMMC vs. Wsh control and WT BMMC vs. KO BMMC; **, P < 0.001 WT control vs. Wsh control, WT BMMC vs. Wsh control and WT BMMC vs. KO BMMC, and P < 0.01 WT control vs. KO BMMC.