Fig. 1.

High-fat fed LH mice exhibit improved glucose tolerance and insulin sensitivity. (A) Blood glucose levels in 16-week high fat diet (HFD)-fed WT or LH mice after an overnight fast (time 0) and at the indicated times after i.p. injection of glucose. *, P < 0.05 by two-way ANOVA and Bonferroni posthoc tests at each point (n = 16). (B) Circulating insulin levels in high-fat fed or overnight fasted mice. Glucose infusion rate (GIR), (C) whole body glucose turnover, glycolysis, and glycogen synthesis (D), and glucose uptake in muscle (E) and fat (F) during hyperinsulinemic/euglycemic clamp. Values are means ± SEM, n = 7–11 (*, P < 0.05). White bars, WT mice; black bars, LH mice.