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Rev-Erbα decreases FGF21 expression in primary hepatocytes. (A) Alignment of human and mouse FGF21 promoter sequences. Capitalized letters correspond to consensus RORE half sites. mRNA expression levels in primary hepatocytes expressing either (B) PGC-1α, (C) Rev-Erbα, or GFP (control). Values are mean ± SD of triplicates expressed relative to GFP, representative of three individual experiments, *, P < 0.05.
