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Apoptosis induction by the PI3K inhibitors involves the executioner caspase. Caspase-2. (A–C). MDA-MB361, MCF-7, and MDA-MB231 cells were incubated either for 48 h with the indicated amount (in nM) of NVP-BEZ235 (A), ZSTK474 (B), or RAD001 (C) for 48 or 3 h with 1 μM of staurosporine (st). The corresponding cell extracts were then analyzed by Western blot for the indicated markers.
