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The structural transition between open and closed CSs. Superimposed conformers obtained from normal mode analysis (A) are compared with thermal ellipsoids (colored by B factor) obtained through anisotropic refinement (B). Two mobile pseudorigid bodies are highlighted: loop 7 above the active site cleft, and a bundle of helices at the rear of the enzyme that move diagonally. The transition is further illustrated in Movies S4 and S5.
