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Temporal effect and dose response curves of intravenous saline (control) and sildenafil (n = 37) on mechanical threshold in rats following ligation of L5/6 spinal nerves. Data are presented as paw withdrawal threshold (A) and %MPE (B). Intravenous sildenafil increased the withdrawal threshold in a dose-dependent manner. Each line or bar represents mean ± SEM. BL, baseline. Compared with control, *p< 0.05, †p< 0.01.
