Table 3.
Associations of Estimated GFR Quartiles with Left Ventricular Hypertrophy, Diastolic Dysfunction, and Systolic Dysfunction
| Estimated GFR Quartiles |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| I >90 |
II 77–90 |
III 63–76 |
IV ≤62 |
||||||
| Range (mL·min·1.73m2) | OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | P for Trend |
| Left ventricular hypertrophy | |||||||||
| Unadjusted | 1.00 | Reference | 0.84 | 0.57–1.24 | 0.84 | 0.57–1.24 | 1.91 | 1.28–2.86 | .003 |
| Adjusted† | 1.00 | Reference | 0.76 | 0.49–1.17 | 0.76 | 0.49–1.18 | 1.65 | 1.03–2.64 | .05 |
| Diastolic dysfunction* | |||||||||
| Unadjusted | 1.00 | Reference | 0.90 | 0.56–1.46 | 1.65 | 1.05–2.60 | 3.05 | 1.93–4.81 | <.001 |
| Adjusted‡ | 1.00 | Reference | 0.52 | 0.30–0.90 | 1.08 | .065–1.81 | 1.36 | 0.79–2.37 | .06 |
| Systolic dysfunction | |||||||||
| Unadjusted | 1.00 | Reference | 0.55 | 0.26–1.15 | 0.59 | 0.29–1.22 | 1.08 | 0.57–2.02 | .79 |
| Adjusted∥ | 1.00 | Reference | 0.74 | 0.32–1.72 | 0.78 | 0.33–1.85 | 1.26 | 0.55–2.89 | .58 |
Excludes participants not in sinus rhythm or with moderate or greater mitral regurgitation. n = 693.
Adjusted for age, sex, race/ethnicity, tobacco use, alcohol use, history of myocardial infarction, serum albumin, and diuretic use.
Adjusted for age, sex, race/ethnicity, tobacco use; history of myocardial infarction, coronary bypass, or diabetes mellitus; systolic blood pressure, anemia, low-density lipoprotein cholesterol, and C-reactive protein.
Adjusted for age, sex, race/ethnicity; history of myocardial infarction, tobacco use, and physical activity; systolic blood pressure, diastolic blood pressure; serum albumin; total, high-density lipoprotein and low-density lipoprotein cholesterol; and aspirin use.