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. 1998 Sep 1;95(18):10949–10953. doi: 10.1073/pnas.95.18.10949

Figure 2.

Figure 2

Effects of various treatments related to SP release in Noci-induced responses. (A) Noci-induced responses in the presence of BoTX at 0 ng (vehicle, ○), 1 fg (▴), 10 fg (⧫), and 100 fg (■). Details of BoTX-treatments were as in the case with PTX (see legend of Fig. 1C). (B) Noci-responses in the presence of vehicle (○), CP-96344 at 10 pmol (■) and CP-96345 at 10 pmol (□). (C) Dose-response curves of Noci- and SP-induced responses in the absence and presence of 10 pmol of CP-96345. (D) A representative trace of the loss of Noci-induced responses after the capsaicin-challenge. Noci and capsaicin were given at doses of 1 fmol and 2 μg, respectively. (E) Dose-response curves of Noci- and SP-induced responses after the treatments with and without capsaicin (⧫, 0.2 μg; ▴, 2 μg). Other details are given the legend of Fig. 1.