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The NFAT–Fos–Jun–DNA quaternary complex (PDB code 1A02). The ARRE2 DNA sequence in the crystal is shown below the figure. Note the deviation from the consensus sequence (TGAGTCA) recognized by AP-1 proteins. Protein–protein interactions between NFAT and the LZ of AP-1 enable the two TFs to bind DNA cooperatively, and regulate coordinately the IL-2 promoter.
