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Results of RRD-251 treatment in vivo
| Experiment | Dosage/Route | Results | p value |
|---|---|---|---|
|
in vivo Matrigel plug angiogenesis |
50 MPK i.p. | 50MPK: 6-fold reduction in relative angiogenesis |
0.0004 |
| A549 Xenograft | 50 MPK i.p 150 MPK-Oral |
Vehicle:1040±128mm3 50 MPK: 145±20 mm3 150 MPK: 148±38 mm3 |
50 MPK:0.0008 150 MPK:0.0004 |
| H1650 Xenograft | 50 MPK i.p. | Vehicle:2185±326mm3 50 MPK:557±76 mm3 |
0.003 |
|
SK-MEL-28/Matrigel Xenograft |
50 MPK i.p. | Vehicle:861±106mm3 50 MPK:341±42 mm3 |
0.0003 |
