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. 2009 May 15;69(2):387–393. doi: 10.1136/ard.2008.105064

Figure 2.

Figure 2

Effect modification by the type of aTNF switch. Change in rheumatoid arthritis (RA) disease activity after initiation of an alternative tumour necrosis factor antagonist (aTNF) versus rituximab (RTX). The longitudinal improvement in RA disease activity (28-joint count Disease Activity Score (DAS28)) over the average time on treatment is represented: (A) for patients switching from one aTNF monoclonal antibody (aTNF-AB) to another aTNF-AB; (B) for patients switching from an aTNF soluble receptor (aTNF-SR) to an aTNF-AB. No significant effect modification existed by the type of aTNF switch (p = 0.27). The progression trajectories depicted are adjusted for differences in baseline disease characteristics and treatment characteristics (supplementary appendix). Vertical lines represent the 95% confidence interval of the mean (only lower-bound interval for the RTX estimates).