Table 1.
Microarray results of the known and novel candidate genes whose expression patterns were examined
| Gene | Probe ID | log fold | n | P-value | Molecular function | Bias |
|---|---|---|---|---|---|---|
| ASER > ASEL | ||||||
| gcy-19 | cea2.i.09274 | 3.10 | 4 | <0.001 | Guanylyl cyclase | ASER |
| K06H6.1 | cea2.i.41240 | 2.54 | 2 | <0.001 | Unknown | – |
| F22B7.3 | cea2.i.19341 | 2.49 | 2 | <0.001 | Unknown | – |
| srxa-5 | cea2.i.18632 | 2.38 | 2 | <0.001 | 7TMR | – |
| nlp-5 | cea2.i.11927 | 2.35 | 4 | <0.001 | Neuropeptide-like | ASER |
| srsx-17 | cea2.i.40237 | 2.31 | 3 | <0.001 | 7TMR | – |
| gcy-3* | cea2.i.14750 | 2.27 | 3 | <0.001 | Guanylyl cyclase | ASER |
| F08B4.4 | cea2.i.25129 | 2.20 | 2 | <0.001 | Unknown | Equal |
| srxa-4 | cea2.i.36881 | 2.17 | 2 | <0.001 | 7TMR | ND |
| srg-41 | cea2.i.44722 | 2.08 | 2 | <0.001 | 7TMR | – |
| K06H6.2 | cea2.d.04545 | 2.05 | 2 | <0.001 | Unknown | – |
| C39D10.5 | cea2.p.136555 | 2.05 | 4 | <0.001 | Unknown | ASER |
| C14C6.3 | cea2.i.33346 | 1.94 | 2 | <0.001 | Unknown | – |
| gcy-13 | cea2.p.114422 | 1.92 | 2 | <0.001 | Guanylyl cyclase | – |
| EGAP5.1 | cea2.i.52221 | 1.89 | 2 | <0.001 | Unknown | ASER |
| ins-3 | cea2.i.18106 | 1.89 | 2 | <0.001 | Insulin like peptide | – |
| str-199 | cea2.d.46339 | 1.88 | 2 | <0.001 | 7TMR | – |
| gcy-22* | cea2.p.123255 | 1.77 | 3 | <0.001 | Guanylyl cyclase | ASER |
| F08G12.8 | cea2.p.139395 | 1.75 | 4 | <0.001 | Unknown | ASER |
| gcy-4* | cea2.i.18253 | 1.72 | 2 | <0.001 | Guanylyl cyclase | ASER |
| nlp-25 | cea2.i.47134 | 1.64 | 3 | <0.001 | Neuropeptide-like | – |
| K07C5.9 | cea2.c.37161 | 1.64 | 4 | <0.001 | Unknown | ASER |
| nlp-7 | cea2.i.52868 | 1.45 | 3 | <0.001 | Neuropeptide-like | ASER |
| ins-4 | cea2.i.18097 | 1.40 | 2 | <0.001 | Insulin like peptide | – |
| gcy-5* | cea2.i.18285 | 1.23 | 3 | 0.002 | Guanylyl cyclase | ASER |
| trp-2 | cea2.d.08009 | 1.15 | 2 | 0.002 | TRPC channel | ASER |
| hen-1* | cea2.c.42027 | 0.44 | 2 | 0.078 | LDL motif protein | ASER |
| fozi-1* | cea2.p.67529 | 0.28 | 3 | 0.101 | Transcription factor | ASER |
| ASEL > ASER | ||||||
| gcy-7* | cea2.p.117523 | −3.71 | 4 | <0.001 | Guanylyl cyclase | ASEL |
| gcy-20* | cea2.i.37357 | −2.01 | 3 | <0.001 | Guanylyl cyclase | ASEL |
| gcy-6* | cea2.3.00146 | −1.73 | 2 | <0.001 | Guanylyl cyclase | ASEL |
| ins-32 | cea2.i.17635 | −1.65 | 2 | <0.001 | Insulin like peptide | ASEL |
| gcy-14* | cea2.i.48658 | −1.60 | 4 | <0.001 | Guanylyl cyclase | ASEL |
| ugt-56 | cea2.p.123534 | −1.39 | 4 | <0.001 | UDP-glucuronosyltransferase | Equal |
| F26C11.3 | cea2.p.37582 | −1.21 | 2 | <0.001 | Unknown | – |
| C08F11.7 | cea2.i.23393 | −1.21 | 2 | <0.001 | Unknown | ND |
| C36F7.2 | cea2.p.04051 | −1.15 | 4 | <0.001 | Unknown | – |
| gcy-17 | cea2.p.18940 | −1.08 | 2 | 0.002 | Guanylyl cyclase | – |
| lim-6* | cea2.p.149121 | −0.53 | 2 | 0.027 | Transcription factor | ASEL |
| flp-20* | cea2.p.138754 | −0.10 | 2 | 0.832 | FMRFamide-like | ASEL |
| flp-4* | cea2.c.10142 | 0.04 | 3 | 0.954 | FMRFamide-like | ASEL |
Microarray results for the genes whose expression patterns were examined by reporter analysis and those known for the lateralized expression (indicated by asterisk) to ASER or ASEL. ‘log fold’ indicates the averaged log2(ASER/ASEL) value. ‘n’ refers to the number of detection through the four sets of microarray experiments. ‘Molecular function’ of each gene is based on the description of WormBase (WS170). ‘ASER’ and ‘ASEL’ in the ‘Bias’ column indicate the respective expression bias within ASE neurons as determined by promoter-fused reporter experiments, whereas ‘-’ indicates the absence of the expression in ASE despite expression in other cells. ‘ND’ indicates that the expression was not observed throughout the body and hence the expression pattern could not be determined. Genes in bold face are newly identified genes in this study.