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. 2009 Oct 25;38(1):26–38. doi: 10.1093/nar/gkp876

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© The Author(s) 2009. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Keywords found by Martini from cell-cycle genes. The figure shows all keywords found by Martini using 600 cell-cycle-regulated genes that have been experimentally assigned to specific time points within the human cell cycle. Percentage numbering indicates cell cycle progress, with cell division occurring at 100% or 12 o’clock. The arc spanned by each keyword shows the exact region where it is statistically significant. The radius of each keyword is determined by word length. The left-portion of the figure shows keywords that describe biological processes and functions—these keywords cluster into three distinct phases: M-, S- and a pre-replication phase. The right-portion of the figure is a close-up of the pre-replication and S-phase regions showing keywords that specify genes, proteins or complexes. The keywords shown, and their positions show a surprisingly accurate and precise match to the sub-phases, processes, and entities known to occur in the cell cycle (see also Table 3).