Table 3.

Characteristics of Case Probands and Their Qualifying (First) Primary Invasive Melanoma by Study Center, and Comparison With All Melanomas Identified in the Same Region and for the Same Age Group at the Population-based Cancer Registries, Australian Melanoma Family Study, 2001–2005^a

	Brisbane				Sydney				Melbourne				Total
	AMFS		Registry, %b	P Valuec	AMFS		Registry, %b	P Valuec	AMFS		Registry, %b	P Valuec	AMFS
	No.	%			No.	%			No.	%			No.	%
Total, cases	234				169				226				629
Sex
Male	99	42.3	45.8		71	42.0	48.3		73	32.3	40.5		243	38.6
Female	135	57.7	54.2	0.45	98	58.0	51.7	0.16	153	67.7	59.5	0.04	386	61.4
Age at diagnosis, years
Median	33.1		32		32.7		32		33.3		32		32.9
18–24	40	17.1	13.4		13	7.7	11.8		25	11.1	14.8		78	12.4
25–29	41	17.5	24.4		33	19.5	19.8		49	21.7	20.0		123	19.6
30–34	67	28.6	21.8		60	35.5	33.0		64	28.3	29.2		191	30.4
35–39	86	36.8	40.3	0.10	63	37.3	35.4	0.51	88	38.9	36.0	0.53	237	37.7
Country of birth
Australia	208	88.9	85.9		137	81.5	84.5		198	87.6	89.2		543	86.5
New Zealand	9	3.8	6.3		8	4.8	2.5		4	1.8	1.5		21	3.3
United Kingdom, Ireland	9	3.8	5.5		12	7.1	4.7		10	4.4	4.4		31	4.9
Other	8	3.4	2.3	0.58	11	6.5	8.2	0.35	14	6.2	4.9	0.94	33	5.3
Unknown	0				1				0				1
Breslow thickness, mm
Median	0.50		0.50		0.65		0.60		0.60				0.55
0.01–1.00	195	83.3	86.2		125	74.4	75.3		185	82.6	80.1		505	80.7
1.01–2.00	31	13.2	10.3		29	17.3	15.3		23	10.3	10.9		83	13.3
2.01–4.00	6	2.6	3.4		6	3.6	6.2		10	4.5	5.6		22	3.5
>4.00	2	0.9	0.1	0.67	8	4.8	3.1	0.42	6	2.7	3.4	0.86	16	2.6
Unspecified	0				1				2				3
Anatomic site
Face, ears	15	6.5	4.3		12	7.1	6.6		16	7.1	6.7		43	6.9
Neck, scalp	12	5.2	6.5		15	8.9	6.6		15	6.7	5.4		42	6.7
Trunk	92	39.8	37.9		52	30.8	37.8		72	32.1	35.6		216	34.6
Upper limb including shoulder	55	23.8	19.8		32	18.9	20.7		47	21.0	20.8		134	21.5
Lower limb including hip	57	24.7	31.5	0.38	58	34.3	28.3	0.35	74	33.0	31.5	0.90	189	30.3
Unspecified	3				0				2				5
Histology
Superficial spreading	163	69.7	75.2		74	43.8	54.2		123	54.4	0.0		360	57.2
Not otherwise specified	52	22.2	18.9		87	51.5	35.6		84	37.2	92.6d		223	35.5
Nodular	14	6.0	4.2		3	1.8	6.9		12	5.3	0.0		29	4.6
Other subtypese	5	2.1	1.7	0.56	5	3.0	3.3	0.001	7	3.1	7.4	<0.001	17	2.7
Index of relative socioeconomic disadvantage, quintilesf
1 (most disadvantage)	12	5.2	6.3		7	4.3	11.4		22	10.1			41	6.7
2	53	23.1	16.0		23	14.3	7.5		56	25.7			132	21.7
3	78	34.1	18.9		29	18.0	7.3		53	24.3			160	26.3
4	44	19.2	27.7		48	29.8	33.0		41	18.8			133	21.9
5 (least disadvantage)	42	18.3	31.0	<0.001	54	33.5	40.7	<0.001	46	21.1			142	23.4

Abbreviations: AMFS, Australian Melanoma Family Study; SEIFA, Socioeconomic Indexes for Areas.

^aMissing or unknown data are excluded from percentage calculations.

^bThese data were obtained from the population-based cancer registries and represent all subjects from the Brisbane, Sydney, and Melbourne metropolitan regions, respectively, who were diagnosed with primary invasive melanoma during the study accrual period (from July 1, 2000, to December 31, 2002) and in the same age group (aged 18–39 years at the time of diagnosis).

^cχ² test for association comparing the distribution of melanoma risk factors between AMFS subjects and individuals identified by the cancer registry and excluding missing/unknown data. P values are 2 sided.

^dDuring this period, the Victorian cancer registry did not code the histology of all melanoma subtypes, so, apart from some of the rarer morphologies, most melanomas including “superficial spreading” and most “nodular” were coded to “not otherwise specified.”

^eOther histologic subtypes (total number of AMFS cases) include the following: malignant melanoma, regressing (n = 9); lentigo maligna melanoma (n = 3); acral lentiginous melanoma (n = 3); and desmoplastic melanoma (n = 2).

^fBased on 2001 SEIFA data published by the Australian Bureau of Statistics (www.abs.gov.au), by use of state-wide quintiles. The Index ranks areas on the level of social and economic well-being based on area of residence. SEIFA data were not available from the Victorian cancer registry for Melbourne.