Table 3.
Risk of Endometrial Cancer in Relation to Use of NSAIDs for at Least 6 Months, by Body Mass Index, Western Washington, 2003–2005a
| Body Mass Index | ||||||||||||
| <30 kg/m2 | ≥30 kg/m2 | |||||||||||
| Cases (N = 214) | Controls (N = 278) | Odds Ratiob | 95% Confidence Interval | Cases (N = 184) | Controls (N = 67) | Odds Ratiob | 95% Confidence Interval | |||||
| No. | % | No. | % | No. | % | No. | % | |||||
| Never usersc | 119 | 54.09 | 156 | 54.93 | 1.00 | Referent | 75 | 39.68 | 34 | 47.22 | 1.00 | Referent |
| Ever users | 101 | 45.91 | 128 | 45.07 | 0.95 | 0.65, 1.38 | 114 | 60.32 | 38 | 52.78 | 1.24 | 0.68, 2.26 |
| Duration of use, years | ||||||||||||
| Never usersc | 119 | 55.87 | 156 | 55.52 | 1.00 | Referent | 75 | 40.98 | 34 | 47.89 | 1.00 | Referent |
| 0.5–9.9 | 63 | 29.58 | 92 | 32.74 | 0.85 | 0.56, 1.30 | 70 | 38.25 | 22 | 33.99 | 1.34 | 0.68, 2.64 |
| ≥10 | 31 | 14.55 | 33 | 11.74 | 1.12 | 0.63, 1.99 | 38 | 20.77 | 15 | 21.13 | 0.90 | 0.40, 2.01 |
| Time since last use, years | ||||||||||||
| Never usersc | 119 | 55.87 | 156 | 55.52 | 1.00 | Referent | 75 | 40.98 | 34 | 47.89 | 1.00 | Referent |
| <5 | 66 | 30.99 | 93 | 33.10 | 0.87 | 0.57, 1.32 | 76 | 41.53 | 29 | 40.85 | 1.08 | 0.57, 2.04 |
| ≥5 | 28 | 13.15 | 32 | 11.39 | 1.07 | 0.59, 1.92 | 32 | 17.49 | 8 | 11.27 | 1.51 | 0.58, 3.92 |
Abbreviation: NSAIDs, nonsteroidal antiinflammatory drugs (including aspirin and all other reported NSAIDs but excluding acetaminophen).
Numbers might not add to total because of missing values.
Adjusted for age, county of residence, calendar year, body mass index (continuous), and hormone therapy use.
Never users of any type of NSAID for more than 5 days per month for at least 6 consecutive months.