Fig. 5.

Hierarchical clustering of genes associated with differential binding sites in MCF7 and MCF7 + E2 cell lines and their associated Pol II binding patterns. (a) Binding patterns in MCF7 control and (b) binding patterns in MCF7 + E2. Red and blue color on the heatmap represent high- and low-binding quantity, respectively. Colored clusters indicate the different grouping based on their Pol II binding patterns. Genes in yellow cluster show high binding near their 3′ end. Cyan clustered genes show high binding around their 5′ end. Genes in green cluster tends to have high binding anywhere along the 3′ and 5′ ends. The genes clustered in both heatmap are identical.