(A) Lesion volumes 24 hours after TBI (n=4–5 mice per group) and (B) lesion volumes 7 days after TBI (n=4–5 mice per group). All lesion volumes are mean ± SEM. (C,D,E) Representative Cresyl violet staining of brain sections 24 hours after TBI, in vehicle, single-dose and sham-operated mice, respectively. (F,G,H) Cresyl violet staining of brain sections 7 days after TBI, in vehicle, single-dose and multi-dose APC treated mice, respectively.