Table 1. HIV-1 drug-resistance mutation lists.
| ANRS | IAS | REGA | STAN | SDRM | ||
|---|---|---|---|---|---|---|
| Nucleoside reverse-transcriptase inhibitors mutations* | ||||||
| M41 | L | L | L | L | L | |
| E44 | D | – | A/D | – | – | |
| A62 | – | V | – | – | – | |
| K65 | R | R | N/R | N/R | R | |
| D67 | N | N | G/N/del | N | E/N/G | |
| T69 | D/N/S/i | i | A/N/D/G/i | i | D/i | |
| K70 | R | E/R | E/G/R | E/G/R | E/R | |
| L74 | I/V | V | I/V | I/V | I/V | |
| V75 | A/M/S/T | I | A/I/M/S/T | I/M/T | A/M/S/T | |
| F77 | – | L | L | L | L | |
| Y115 | F | F | F | F | F | |
| F116 | – | Y | Y | Y | Y | |
| V118 | – | – | I | – | – | |
| Q151 | M | M | M | M | M | |
| M184 | I/V | I/V | I/V | I/V | I/V | |
| L210 | W | W | W | W | W | |
| T215 | Mul‡ | F/Y | Mul‡ | F/Y | C/D/E/F/I/S/V/Y | |
| K219 | E/Q | E/Q | E/H/N/R/Q | E/Q | E/N/R/Q | |
| Non-nucleoside reverse-transcriptase inhibitors mutations* | ||||||
| V90 | I | I | I | – | – | |
| A98 | G/S§ | G | G | G | – | |
| L100 | I | I | I | I | I | |
| K101 | E/P | E/H/P | E/H/N/P/Q | E/P | E/P | |
| K103 | H/N/S/T | N | H/N/R/S/T | N/S | N/S | |
| V106 | A/I/M | A/I/M | A/I/M | A/M | A/M | |
| V108 | – | I | I | I | – | |
| E138 | – | A | K/Q | – | – | |
| V179 | D/F | D/F/T | D/E | D/E/F | F | |
| Y181 | C/I/V | C/I/V | C/I/V | C/I/V | C/I/V | |
| Y188 | C/L/H | C/L/H | C/L/H | C/L/H | C/L/H | |
| G190 | Mul¶ | A/S | Mul¶ | A/E/S | A/E/S | |
| H221 | – | – | Y | – | – | |
| P225 | H | H | H | H | H | |
| F227 | – | – | C/L | C/L | – | |
| M230 | L | L | I/L | L | L | |
| P236 | – | – | L | L | – | |
| K238 | – | – | N/T | T | – | |
| Y318 | – | – | F | – | – | |
| Protease inhibitors mutations* | ||||||
| L10 | F/I/M/R/V | C/F/I/R/V | I/F/V/Y | – | – | |
| V11 | I | I | I/L | – | – | |
| I13 | – | V | – | – | – | |
| I15 | A/V | – | – | – | – | |
| G16 | E | E | – | – | – | |
| K20 | I/M/R/T | I/M/R/T/V | I/M/R/T/V | – | – | |
| L23 | – | – | I | I | I | |
| L24 | I | I | F/I | I | I | |
| D30 | N | N | N | N | N | |
| V32 | I | I | I/L | I | I | |
| L33 | F/I/V | F/I/V | F/I/M/V | F | – | |
| E34 | – | Q | V | – | – | |
| E35 | – | G | G/N | – | – | |
| M36 | I/L/V | I/L/V | – | – | – | |
| L38 | – | – | W | – | – | |
| R41 | – | – | I/T | – | – | |
| K43 | – | T | R/T | – | – | |
| K45 | – | – | I | – | – | |
| M46 | I/L | I/L | I/L | I/L | I/L | |
| I47 | A/V | A/V | A/V | A/V | A/V | |
| G48 | V | V | A/M/V | M/V | M/V | |
| I50 | L/V | L/V | L/V | L/V | L/V | |
| F53 | L/W/Y | L/Y | L | L | L/Y | |
| I54 | A/L/M/S/T/V | A/L/M/S/T/V | A/C/L/M/S/T/V | A/L/M/T/V | A/L/M/S/T/V | |
| Q58 | E | E | E | - | – | |
| D60 | E | E | – | – | – | |
| I62 | V | V | V | – | – | |
| L63 | P | P | – | – | – | |
| I64 | – | L/M/V | M/V | – | – | |
| I66 | – | – | F | – | – | |
| H69 | I/K/N/Q/R/Y | K | – | – | – | |
| K70 | – | – | E | – | – | |
| A71 | I/L/T/V | I/L/T/V | I/L/T/V | – | – | |
| G73 | A/S/T | A/C/S/T | A/C/F/S/T/V | S/T | A/C/S/T | |
| T74 | P | P | A/E/S/P | – | – | |
| L76 | V | V | V | V | V | |
| V77 | I | I | A/T/V | – | – | |
| V82 | A/C/G/F/M/S/T | A/F/L/I/S/T | A/F/L/M/S/T | A/F/L/S/T | A/C/F/L/M/S/T | |
| N83 | – | D | D | – | D | |
| I84 | A/V | V | A/C/V | A/C/V | A/C/V | |
| I85 | V | V | V | – | V | |
| N88 | D/S | D/S | D/S | D/S | D/S | |
| L89 | I/M/R/T/V | V | I/T/V | – | – | |
| L90 | M | M | M | M | M | |
| I93 | – | L/M | M | – | – | |
| C95 | – | – | F | - | - | |
Positions in bold have mutations that appear in all five lists.
Wild-type amino acid (for consensus subtype B sequence) and reverse transcriptase or protease position.
ANRS: T215A/C/D/E/F/G/H/I/L/N/S/V/Y.
For subtype C only.
ANRS: G190A/C/E/Q/S/T/V.
–: Mutation not on list; A: Alanine; ANRS: The French National Agency for AIDS Research, v17 [302]; C: Cysteine; D: Aspartic acid; del: Deletion; E: Glutamic acid; F: Phenylalanine; G: Glycine; H: Histidine; i: Insertion; I: Isoleucine; IAS: International AIDS Society–USA; K: Lysine; L: Leucine; M: Methionine; Mul: Multiple mutations; N: Asparagine; P: Proline; Q: Glutamine; R: Arginine; REGA: Rega Institute mutation list [304]; S: Serine; SDRM: Surveillance drug-resistance mutation list; STAN: Stanford University HIV Drug Resistance Database [303]; T: Threonine; V: Valine; W: Tryptophan; Y: Tyrosine.