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(Upper) Comparison of the effects of i.c.v. P and 3α,5αTHP infused at either 2.2 μg/min (Left) or 0.22 μg/min (Right) on LH pulsatility. P administered i.c.v. replicated the suppression of LH produced by intravaginal P implants. In contrast, i.c.v. administered 3α,5αTHP did not modify LH pulsatility. (Lower) LH pulse frequency (mean ± SEM) and mean LH concentration over the three 3-hr periods. LH pulses are noted by solid symbols. ∗, P < 0.05; ∗∗∗, P < 0.001.
