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In the absence of a 2-week E priming period before P insertion, P had no significant effect on LH pulsatility (Top), whereas after an E-priming period (Middle), the suppressive power of P was restored. (Bottom) LH pulse frequency and level over the three 3-hr periods (mean ± SEM). LH pulses are noted by solid symbols and shaded bars mark the period that P is present. ∗, P < 0.05; ∗∗, P < 0.01; ∗∗∗, P < 0.001.
