Persistent elevation of ESR despite an asymptomatic clinical course for patients 2-7. A) ESR levels depicted for each patient over the examined intervals. Data from each patient correspond to the following colored lines: Patient 2 (Purple), 3 (Red), 4 (Orange), 5 (Light blue), 6 (Brown), and 7 (Black). B) Control ESR levels from 2 female patients with a combined immunodeficiency (Gray line and Blue dashed line) and 2 male patients with CD40 ligand deficiency (Red line and Black dots). These patients were between 8 and 28 years of age.