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. Author manuscript; available in PMC: 2009 Dec 31.
Published in final edited form as: J Immunol. 2009 Mar 1;182(5):2665–2671. doi: 10.4049/jimmunol.0802221

Figure 4.

Figure 4

Blockade of TGFβ recovered normal Th1 responses against the MOG peptide in IL-17RA −/− mice. Wild type mice (WT), IL-17RA +/− (Het), and IL-17RA −/− littermates were immunized with MOG35–55 peptide to elicit EAE. Anti-TGFβ antibodies were administered at day 5 and day 9. At ten days post-immunization, lymphocytes were isolated from draining lymph nodes and stimulated with MOG35–55 peptide as described in Materials and Methods. Frequencies of CD4+ T cells that made IL-17 (A) (C) or IFN-γ (B) (D) among total lymphocytes were determined by intracellular cytokine staining assay. More than seven mice were used in each experimental group. Student T test was performed.