Table 3.

Penetrance tables: 3-way interactions.

Model 1
	3rd factor = cc			3rd factor = Cc			3rd factor = CC
	Bb	Bb	BB	bb	Bb	BB	bb	Bb	BB
aa	0.007	0.007	0.007	0.007	0.007	0.007	0.007	0.007	0.007
Aa	0.007	0.007	0.007	0.007	0.12	0.007	0.007	0.007	0.007
AA	0.007	0.007	0.007	0.007	0.007	0.007	0.007	0.007	0.12
Model 2
	3rd factor = cc			3rd factor = Cc			3rd factor = CC
	bb	Bb	BB	bb	Bb	BB	bb	Bb	BB
aa	0.007	0.007	0.12	0.007	0.007	0.12	0.12	0.12	0.73
Aa	0.007	0.007	0.12	0.007	0.007	0.12	0.12	0.12	0.73
AA	0.12	0.12	0.73	0.12	0.12	0.73	0.73	0.73	0.98
Model 3
	3rd factor = cc			3rd factor = Cc			3rd factor = CC
	bb	Bb	BB	bb	Bb	BB	bb	Bb	BB
aa	0.007	0.007	0.27	0.007	0.007	0.27	0.007	0.007	0.27
Aa	0.007	0.007	0.27	0.007	0.007	0.27	0.007	0.007	0.27
AA	0.27	0.27	0.007	0.27	0.27	0.50	0.27	0.27	0.73
Model 4
	3rd factor = cc			3rd factor = Cc			3rd factor = CC
	bb	Bb	BB	bb	Bb	BB	bb	Bb	BB
aa	0.007	0.007	0.007	0.007	0.007	0.007	0.007	0.007	0.12
Aa	0.007	0.007	0.007	0.007	0.007	0.007	0.007	0.007	0.12
AA	0.007	0.007	0.12	0.007	0.007	0.12	0.12	0.12	0.98
Model 5
	3rd factor = cc			3rd factor = Cc			3rd factor = CC
	bb	Bb	BB	bb	Bb	BB	bb	Bb	BB
aa	0.007	0.12	0.007	0.007	0.12	0.007	0.007	0.12	0.007
Aa	0.007	0.12	0.007	0.007	0.12	0.007	0.007	0.12	0.007
AA	0.007	0.12	0.007	0.007	0.12	0.007	0.007	0.12	0.12
Model 6
	3rd factor = cc			3rd factor = Cc			3rd factor = CC
	bb	Bb	BB	bb	Bb	BB	bb	Bb	BB
aa	0.007	0.007	0.12	0.007	0.007	0.12	0.12	0.12	0.73
Aa	0.007	0.007	0.12	0.007	0.007	0.12	0.12	0.12	0.73
AA	0.12	0.12	0.73	0.12	0.12	0.73	0.007	0.007	0.12

Penetrance tables of six different models with 3-way interactions. SNP1 has three genotypes AA, Aa, aa and SNP2 has three different genotypes BB, Bb, bb and SNP 3 has three different genotypes CC, Cc, cc. Each cell of a penetrance table represents the probability of being affected given the cell genotype.