Table 5.
Results from single SNP association analyses: Top 20 SNPs showing significant association with acute rejection according to Fisher's exact test. The p values are not corrected for multiple testing.
| SNPs | genes | pvalue | (Putative) Function |
|---|---|---|---|
| rs2147668 | RFC3 | 0.0001 | Replication factor C 3 |
| rs875740 | ABCC1 | 0.0006 | plasma membrane drug-efflux pump |
| rs2238136 | VDR | 0.0009 | Vitamin D receptor |
| rs4988515 | IGFBP1 | 0.0009 | Insulin-like growth factor binding protein 1 |
| rs442332 | TNFRSF17 | 0.0009 | B-cell maturation factor |
| rs2211463 | Admixture | 0.0010 | Unknown |
| rs2189394 | Admixture | 0.0012 | Unknown |
| rs2741045 | UGT1A9 | 0.0013 | Drug metabolizing enzyme |
| rs288326 | FRZB | 0.0013 | frizzled-related protein |
| rs1049897 | MGP | 0.0014 | Regulator of cartilage development |
| rs10276036 | ABCB1 | 0.0015 | Initiate T lymphocyte-mediated immunity |
| rs1800875 | CMA1 | 0.0019 | Degradation of the extracelluar matrix |
| rs4072037 | MUC1 | 0.0021 | encodes a mucin glycoprotein(s) |
| rs11539762 | MYEOV | 0.0023 | myeloma overexpressed gene |
| rs2241339 | ABCB11 | 0.0024 | Progressive intrahepatic cholestasis-2 |
| rs2741046 | UGT1A9 | 0.0028 | Drug metabolizing enzyme |
| rs2014800 | ABCC1 | 0.0030 | plasma membrane drug-efflux pump |
| rs2695232 | SOD3 | 0.0031 | superoxide dismutase 3 |
| rs1052369 | ANKRD29 | 0.0033 | ankyrin repeat domain 29 |
| rs2305030 | LTK | 0.0033 | leukocyte receptor tyrosine kinase |