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. Author manuscript; available in PMC: 2009 Dec 31.
Published in final edited form as: J Cell Biochem. 2009 Dec 15;108(6):1244–1251. doi: 10.1002/jcb.22367

TABLE II.

RNase P and RNase MRP in vitro and in vivo Substrates/Inhibitors

Bacteria Eukarya
RNase P Nuclear RNase P RNase MRP
Pre-tRNA Pre-tRNA Pre-rRNA (A3 site)
Mitochondrial RNA primers for DNA replication HRA1 antisense RNA Mitochondrial RNA primers for DNA replication
Pre-4.5S RNA Box C/D intron encoded snoRNA CLB2 mRNA
C4 RNA Long non-coding RNA (lncRNA)
tmRNA (10Sa RNA & Cyanelle) Pre-rRNA (multiple sites)
TYMV Virus RNA
ColE1 RNA Inhibitors
Polycistronic mRNA Poly-nucleotides (G>U>A≫C)
Riboswitches (transient structures) ssRNA (mixed sequences)
Small RNA (>5 nt)
Φ-80 induces RNA
Long non-coding RNA (lncRNA)

Not all substrates or inhibitors have been shown to be physiologically relevant, illustrating the promiscuity of RNase P in vitro.