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. 2009 Oct 1;31(1):100–111. doi: 10.1093/eurheartj/ehp396

Figure 3.

Figure 3

Insulin receptor substrate-1 (IRS1) protein levels and activity in skeletal muscle. (A) Immunoblot of IRS1 protein levels in total cell lysates from skeletal muscle biopsies. Levels of IRS1 were unchanged in patients with non-insulin-dependent diabetes mellitus when compared with controls. (B) Representative immunoblot of phosphotyrosine- IRS1 levels in skeletal muscle extracts as determined by phosphotyrosine immunoprecipitation and insulin receptor substrate-1 immunoblotting. (C) Quantification of total IRS1 levels in skeletal muscle biopsies in patient groups in optical units. (D) Quantification of phosphotyrosine- IRS1 levels in skeletal muscle biopsies in patient groups in optical units. **P = 0.001 vs. control.