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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: J Alzheimers Dis. 2009 Feb;16(2):433–439. doi: 10.3233/JAD-2009-0969

Fig. 2.

Fig. 2

The kinetics of Ac-306 VQIVYK 311 tau peptide aggregation in the absence or presence of Meganatural-Az® GSPE. Ac-306VQIVYK311 tau peptides were aggregated in the absence (No MegN) or presence of varying doses (0.22–22 μM MegN) of Meganatural-Az® GSPE. (A) Accumulations of aggregated tau as a function of time were assessed by measuring ThS fluorescence. Concentrations of the GSPE at 0.22 μM, 2.2 μM and 22 μM correspond to, respectively, 1:10, 1:1, and 10:1 molar ratios of GSPE relative to tau peptides. (B) Maximum accumulation of tau aggregates, calculated as average fluorescent unit from 6–10 min. Bar graphs represent means ± SEM values. One-way ANOVA, p < 0.0001; **p < 0.001, Tukey post hoc pair analysis for no MegN vs. 0.22 μM MegN, 0.22 vs. 2.2 μM MegN, 2.2 vs. 22 μM MegN. Abbreviation: MegN, Meganatural-Az® GSPE.