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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Cancer Metastasis Rev. 2008 Sep;27(3):363–374. doi: 10.1007/s10555-008-9138-7

Figure 1.

Figure 1

Different physiological processes, many of which are not specifically related to the direct instantaneous damage caused by radiation, progress over time to create normal tissue toxicity. Markers are needed at all stages of the process including markers for both the direct effects of the radiation and the indirect and thus potentially reversible radiation effects.