Figure 7.

Dependence on r_tun (for H-transfer) (A and B) and V₀ (C and D) of proton transfer in AADH. κ (for H; solid squares) and the KIE (open circles) are shown in panels A and C; and k_TST (solid squares), k_tun (open circles), and k_obs (solid triangles) are shown in panels B and D. Note that the k_tun and k_obs values are essentially superimposed and the dotted horizontal lines in panels C and D mark the average barrier potential (see Fig. S8). Arrows mark the experimentally observed k_obs and KIE values (38). See text for more details.