Table 1.
The relationship between SNPs in two genes, SOD2 (Val16Ala) and SePP1 (Ala234Thr) with risk of all prostate cancer, non-aggressive prostate cancer and aggressive prostate cancer in the CAPS study.
| Controls | All prostate cancer | Non-aggressive prostate cancer | Aggressive prostate cancer | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | n | n | OR (95% CI)* | P | n | OR (95% CI)* | P | n | OR (95% CI)* | P |
| SOD2 Codon 16 | 1636 | 2634 | 1648 | 986 | ||||||
| Val/Val | 423 | 602 | Referent | 382 | Referent | 220 | Referent | |||
| Ala/Val | 789 | 1352 | 1.21 (1.03 to 1.41) | 0.02 | 854 | 1.21 (1.02 to 1.44) | 0.03 | 498 | 1.21 (0.99 to 1.48) | 0.60 |
| Ala/Ala | 424 | 680 | 1.15 (0.97 to 1.37) | 0.11 | 412 | 1.11 (0.91 to 1.36) | 0.29 | 268 | 1.22 (0.98 to 1.53) | 0.78 |
| Ala/Val + Ala/Ala | 1213 | 2032 | 1.19 (1.03 to 1.37) | 0.02 | 1266 | 1.18 (1.00 to 1.38) | 0.05 | 766 | 1.21 (1.01 to 1.46) | 0.04 |
| SEPP1 Codon 234 | 1570 | 2643 | 1653 | 990 | ||||||
| Ala/Ala | 878 | 1522 | Referent | 951 | 571 | Referent | ||||
| Ala/Thr | 595 | 949 | 0.94 (0.82 to 1.07) | 0.37 | 593 | 0.95 (0.82 to 1.11) | 0.54 | 356 | 0.93 (0.79 to 1.10 | 0.40 |
| Thr/Thr | 97 | 172 | 1.09 (0.83 to 1.42) | 0.54 | 109 | 1.13 (0.84 to 1.52) | 0.42 | 63 | 1.03 (0.74 to 1.44) | 0.86 |
| Ala/Thr + Thr/Thr | 692 | 1121 | 0.96 (0.85 to 1.09) | 0.54 | 702 | 0.98 (0.85 to 1.13) | 0.76 | 419 | 0.94 (0.80 to 1.11) | 0.48 |
*
odds ratio adjusted for age and geographical location, 95% confidence interval
n = Number of subjects