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. 2009 Oct 21;29(42):13377–13388. doi: 10.1523/JNEUROSCI.1127-09.2009

Figure 2.

Figure 2.

Nerve injury-induced upregulation of VGF in DRG neurons. A–C, VGF-IR increased dramatically 1 d after SNL (C) and to a lesser extent after sham surgery (B). Corresponding images of YOYO-1 labeling (A′–C′) show all cells in the fields of view shown in A–C. D, Quantitative analysis showed a significant increase in the number of VGF-positive neurons 1 and 7 d after SNL in both injured L5 and uninjured L4 DRG. Sham surgery resulted in a more moderate but significant increase in the number of VGF-positive neurons in L5 DRG at day 1 and day 7 and in L4 DRG at day 1. Significant changes are indicated by * when compared with sham and # when compared with naive (*p < 0.001; **p < 0.05; #p < 0.001; ##p < 0.005; ###p < 0.01; one-way ANOVA and Student–Newman–Keuls test for multiple comparisons; n = 4 in each group).