Table 4.

Multivariate analyses of disease-free survival and overall survival using Cox’s proportional hazard models

Covariate	Estimate	Standard error	Wald chi-square	Hazard ratio	P value
Disease-free survival (month)1
Fractionated ER	−0.13960	0.05628	6.1530	0.870	0.0131
Fractionated PR	−0.10107	0.05869	2.9655	0.904	0.0851
Age <36 years	0.67577	0.29191	5.3592	1.966	0.0206
Lymph node ≥10	1.35863	0.27997	23.5496	3.891	<0.0001
Histology grade III	1.32154	0.61828	4.5687	3.749	0.0326
AJCC stage	0.91674	0.18495	24.5675	2.501	<0.0001
Overall survival (month)2
Fractionated PR	−0.21830	0.06066	12.9512	0.804	0.0003
Lymph node 1–9	0.81272	0.30782	6.9707	2.254	0.0083
Lymph node ≥10	1.56278	0.33739	21.4549	4.772	<0.0001
Histology grade III	0.68063	0.25213	7.2875	1.975	0.0069
Tumor size (cm)	0.32670	0.16657	3.8469	1.386	0.0498
Neoadjuvant or adjuvant chemotherapy	0.61693	0.35181	3.0750	1.853	0.0795
Time lag since recurrence	0.07444	0.00775	92.2451	1.077	<0.0001

¹Cox’s proportional hazard model: n=416, adjusted generalized R ²=0.2486

²Cox’s proportional hazard model: n=416, adjusted generalized R ²=0.3971