Table 3.
Tests for association between MDM2 SNP309 genotypes and SLE, age of disease onset, and nephritis, stratified by ethnicity
| TT no (%) | TG no (%) | GG no (%) | P value | |
|---|---|---|---|---|
| African American | ||||
| SLE (n = 47) | 33 (70) | 12 (26) | 2 (4) | 0.90 |
| Control (n = 122) | 84 (69) | 34 (28) | 4 (3) | |
| European | ||||
| SLE (n = 133) | 37 (28) | 73 (55) | 23 (17) | 0.40 |
| Control (n = 248) | 86 (35) | 123 (50) | 39 (16) | |
| Adjusted odds ratio of SLE vs control (95% CI)a |
1.0 (reference) | 1.22 (0.82–1.83) | 1.28 (0.71–2.31) | 0.56 |
| African American | ||||
| Childhood onset (n = 17)b | 12 (71) | 4 (24) | 1 (6) | 1.0 |
| Adult onset (n = 30) | 21 (70) | 8 (27) | 1 (3) | |
| European | ||||
| Childhood onset (n = 45)b | 12 (27) | 26 (58) | 7 (16) | 0.91 |
| Adult onset (n = 88) | 25 (28) | 47 (53) | 16 (18) | |
| Asian | ||||
| Childhood onset (n = 18)b | 3 (17) | 6 (33) | 9 (50) | 0.77 |
| Adult onset (n = 21) | 4 (19) | 9 (43) | 8 (38) | |
| Adjusted odds ratio of childhood-onset vs adult-onset SLE (95% CI)a |
1.0 (reference) | 1.05 (0.54–2.05) | 1.13 (0.48–2.65) | 0.96 |
| African American | ||||
| Nephritis (n = 23) | 14 (61) | 8 (35) | 1 (4) | 0.33 |
| No nephritis (n = 16) | 13 (81) | 2 (13) | 1 (6) | |
| European | ||||
| Nephritis (n = 50) | 12 (24) | 28 (56) | 10 (20) | 1.00 |
| No nephritis (n = 51) | 13 (25) | 29 (57) | 9 (18) | |
| Asian | ||||
| Nephritis (n = 22) | 1 (5) | 9 (41) | 12 (55) | 0.20 |
| No nephritis (n = 11) | 3 (27) | 4 (36) | 4 (36) | |
| Adjusted odds ratio of nephritis vs non-nephritis SLE (95% CI)a |
1.0 (reference) | 1.65 (0.77–3.52) | 1.88 (0.72–4.86) | 0.34 |
a
Odds ratio (95% CI) adjusted for race in logistic regression.
b
Age at diagnosis <18 years old.