Table 2. Estimated mean responses by clopidogrel dose and time.

The estimated mean responses and standard errors at the two doses (75 mg and 150 mg) are based on a linear mixed model with dose as the predictor and a random effect for each subject. The estimated mean responses and standard errors at the three times (baseline, 30 days, and 60 days) are based on a linear mixed model with time as the predictor and a random effect for each subject. Superscripts 1, 2, 3, and 4 indicate statistically significant differences in platelet response (p < 0.05) compared to 75 mg dose, baseline, 60 days, and 30 days, respectively. PRU = P2Y12 reaction units, MPA = maximal platelet aggregation, RPA = residual platelet aggregation, and ADP = adenosine diphosphate.

Dose and Time	PRU	MPA ADP5	MPA ADP20	RPA ADP5	RPA ADP20
75 mg dose	191 ± 15	40 ± 3	50 ± 3	23 ± 3	36 ± 4
150 mg dose	158 ± 171	36 ± 3	47 ± 3	19 ± 4	33 ± 4
Baseline (75 mg clopidogrel)	191 ± 16	39 ± 3	51 ± 3	23 ± 4	42 ± 43,4
30 days (150 mg clopidogrel)	158 ± 172,3	36 ± 3	47 ± 3	18 ± 4	33 ± 4
60 days (75 mg clopidogrel)	191 ± 17	40 ± 3	49 ± 4	22 ± 4	28 ± 4