Table 4.
Effect modification of the association between a 1-SD increase in BC concentrations and BP (mmHg) by gene variants related to oxidative stress.a
| Change in BP (95% CI) |
||
|---|---|---|
| Genetic variant | SBP | DBP |
|
GSTM1 | ||
| Present (n = 494) | 0.79 (−1.20 to 2.77) | 0.98 (−0.11 to 2.07) |
| Null (n = 527) | 1.84 (−0.12 to 3.81) | 0.76 (−0.23 to 1.74) |
| p-Value for interaction | 0.31 | 0.84 |
|
GSTT1 | ||
| Present (n = 736) | 1.26 (−0.38 to 2.91) | 0.86 (−0.02 to 1.74) |
| Null (n = 206) | 0.56 (−2.59 to 3.71) | −0.09 (−1.44 to 1.62) |
| p-Value for interaction | 0.91 | 0.80 |
|
HMOX-1 microsatellite (GT)n repeat length | ||
| < 25 repeats (n = 122) | −0.33 (−4.80 to 4.14) | 1.16 (−1.01 to 3.32) |
| ≥ 25 repeats (n = 898) | 1.81 (0.34 to 3.29) | 0.81 (0.02 to 1.61) |
| p-Value for interaction | 0.64 | 0.78 |
All counts reported correspond to number of study center visits. Interaction test results represent interactions between BC and variant allele number only. All regression models are adjusted for age, cigarette smoking, pack-years of smoking, season of clinical visit, weekday of clinical visit, body mass index, diabetes status, statin use, fasting glucose level, 7-day moving average of temperature (linear and quadratic), 7-day moving average of relative humidity (linear and quadratic), hour of clinical visit, year of clinical visit, years of education, race/ethnicity, antihypertensive medication use, and daily alcohol intake.