Figure 6.

Mean (± s.e. mean) changes in renin-angiotensin-aldosterone system-related gene expression in (A) tissue samples from normotensive rats after 5 days of treatment with torcetrapib or dalcetrapib and (B) samples of adrenal gland from spontaneously hypertensive rats after 5 days of treatment with torcetrapib (all fold changes greater than 1.5-fold are significant at P < 0.05). AOGEN, angiotensinogen; ACE, angiotensin converting enzyme; AT₁, angiotensin receptor type 1; preproET1, preproendothelin; ECE, endothelin-converting enzyme; ET_A, endothelin receptor A; ET_B, endothelin receptor B; eNOS, endothelial nitric oxide synthase; SGK1, serum/glucocorticoid regulated kinase 1; SR-B1, scavenger receptor class B type 1; StAR, steroidogenic acute regulatory protein.