Table 2.
Changes (mean ± s.e. mean) in AP and heart rate in SHR and normotensive rats treated with torcetrapib on day 1 (data expressed as difference from placebo group)
| Torcetrapib dose | Mean AP (mmHg) | Systolic AP (mmHg) | Diastolic AP (mmHg) | Heart rate (bpm) |
|---|---|---|---|---|
| SHR | ||||
| 10 mg·kg−1·day−1 | 2.7 ± 0.8 | 2.7 ± 0.8 | 2.5 ± 0.8 | 7.1 ± 1.9 |
| 40 mg·kg−1·day−1 | 6.5 ± 0.6* | 7.3 ± 0.9* | 5.3 ± 0.6* | 7.2 ± 2.2 |
| 80 mg·kg−1·day−1 | 7.8 ± 3.9 | 7.8 ± 3.5 | 7.9 ± 4.5 | 2.8 ± 3.4 |
| Normotensive rats | ||||
| 10 mg·kg−1·day−1 | 1.4 ± 0.9 | 1.9 ± 1.0 | 1.0 ± 0.8 | 4.0 ± 3.7 |
| 40 mg·kg−1·day−1 | 3.7 ± 1.0 | 4.9 ± 1.0* | 2.3 ± 1.0 | −0.3 ± 4.7 |
| 80 mg·kg−1·day−1 | 2.6 ± 1.4 | 3.3 ± 1.5 | 1.7 ± 1.1 | −10.7 ± 6.6 |
*
P < 0.05 vs. placebo.
AP, arterial pressure; bpm, beats per minute; SHR, spontaneously hypertensive rat.