. 2009 Nov 3;158(7):1835–1847. doi: 10.1111/j.1476-5381.2009.00468.x

Table 1.

Effect of prophylactic and therapeutic administration of theophylline on the changes in the left ankle diameter (mm) of adjuvant arthritic rats

Drug treatment	Change in left ankle diameter (mm)
	Prophylactic		Therapeutic
	Day 14	Day 30	Day 25	Day 30
Saline-treated non-arthritic rats (group I)	0	0^*	0	0^*
Untreated arthritic rats (group II)	0.1 ± 0.01	0.34 ± 0.01	0.38 ± 0.02	0.34 ± 0.01
Theophylline-treated (45 mg·kg⁻¹·day⁻¹) arthritic rats (groups III)	0	0^*	0.11 ± 0.01^*	0.1 ± 0.001^*
Theophylline-treated (30 mg·kg⁻¹·day⁻¹) arthritic rats (groups IV)	0	0^*	0.14 ± 0.04^*	0.12 ± 0.02^*
Theophylline-treated (15 mg·kg⁻¹·day⁻¹) arthritic rats (groups V)	0	0^*	0.16 ± 0.02^*	014 ± 0.01^*
Theophylline (30 mg·kg⁻¹·day⁻¹) in combination with SNP (1 mg·kg⁻¹·day⁻¹) (groups VI)	0.1 ± 0.01	0.1 ± 0.01^*	0.13 ± 0.01^*	0.15 ± 0.03^*
Theophylline (30 mg·kg⁻¹·day⁻¹) in combination with SNP (0.01 mg·kg⁻¹·day⁻¹) (groups VII)	0	0^*	0.13 ± 0.01^*	0.1 ± 0.01^*
Theophylline (30 mg·kg⁻¹·day⁻¹) in combination with L-NMMA (30 mg·kg⁻¹·day⁻¹) (groups VIII)	0	0^*	0.11 ± 0.01^*	0.1 ± 0.01^*

P < 0.05 versus group II.

L-NMMA, L-N^G-monomethyl arginine; SNP, sodium nitroprusside.