Table 4.
Effect of prophylactic theophylline alone or in combination with either SNP or L-NMMA on serum levels of TNF-α and IL-10 in adjuvant arthritic rats
| Group | Drug treatment |
Serum levels (pg) |
|
|---|---|---|---|
| TNF-α | IL-10 | ||
| I | Saline-treated (non-adjuvant) | 30.7 ± 2.3 | 345.6 ± 44.4† |
| II | Adjuvant arthritis (untreated) | 31.04 ± 1.4 | 171.6 ± 24* |
| III | Theophylline-treated (45 mg·kg−1·day−1) | 27.2 ± 1.8 | 340 ± 38.6† |
| IV | Theophylline-treated (30 mg·kg−1·day−1) | 27.8 ± 1.22 | 286.5 ± 31.7† |
| V | Theophylline-treated (15 mg·kg−1·day−1) | 28.3 ± 1.8 | 275 ± 32.4† |
| IV | Theophylline-treated (30 mg·kg−1·day−1) in combination with SNP (1 mg·kg−1·day−1) | 28.8 ± 0.7 | 340.9 ± 60.6† |
| VII | Theophylline (30 mg·kg−1·day−1) in combination with SNP (0.01 mg·kg−1·day−1) | 30.2 ± 2.4 | 312.2 ± 43.4† |
| VIIII | Theophylline (30 mg·kg−1·day−1) in combination with L-NMMA (30 mg·kg−1·day−1) | 29.6 ± 3.7 | 293.6 ± 28.8† |
Samples were taken from rats on day 30 after adjuvant inoculation.
*
P < 0.05 versus saline-treated non-arthritic rats (group I).
†
P < 0.05 versus saline-treated arthritic rats (group II).
IL-10, interleukin-10; L-NMMA, L-NG-monomethyl arginine; SNP, sodium nitroprusside; TNF-α, tumour necrosis factor–α.