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2G12 IgG CD measurements and 2G12 Fab specificity ELISA on recombinant gp160. A, the CD spectra in the near-UV range revealed no major structural differences between IgG1 2G12-wt and IgG1 2G12-JH3. IgG1 2G12-GL already exhibited a slight apparent structural change. In contrast, the spectrum of IgG1 2G12-3H6 suggested major structural changes compared with IgG1 2G12-wt. B, only 2G12-wt Fab was able to bind to recombinant gp160 MN.
