TABLE 1.

Gene expression profiles in 16-week-old mice

Data are mean ± S.D. from 5–6 tibias of 6-week-old individual mice and expressed as the -fold changes relative to the housekeeping gene cyclophilin A subsequently normalized to control (Pkd1^flox/+) mice.

Gene	Accession no.	Oc-Cre;Pkd1flox/+	Pkd1flox/m1Bei	Oc-Cre;Pkd1flox/m1Bei	p value
Osteoblast lineage
Runx2-II	NM_009820	0.73 ± 0.04a	0.71 ± 0.08a	0.45 ± 0.07a,b	0.0007
Runx2-I	D14636	1.14 ± 0.32	1.16 ± 0.14	1.15 ± 0.18	0.5961
Runx2	NM_009820	0.73 ± 0.09a	0.71 ± 0.16a	0.51 ± 0.07a,b	0.0009
Osteocalcin	NM_007541	0.82 ± 0.12a	0.80 ± 0.11a	0.46 ± 0.08a,b	<0.0001
Osteopontin	AF515708	0.73 ± 0.11a	0.69 ± 0.11a	0.44 ± 0.03a,b	0.0027
Bsp	NM_008318	0.73 ± 0.07a	0.71 ± 0.08a	0.52 ± 0.06a,b	<0.0001
Opg	MMU94331	0.71 ± 0.15a	0.70 ± 0.11a	0.68 ± 0.20a	0.0295
Rank ligand	NM_011613	0.70 ± 0.12a	0.57 ± 0.07a	0.39 ± 0.07a,b	<0.0001
Mmp13	NM_008607	0.97 ± 0.16	0.65 ± 0.05a	0.43 ± 0.11a,b	<0.0001
Dmp1	MMU242625	0.71 ± 0.06a	0.64 ± 0.12a	0.40 ± 0.05a,b	<0.0001
Phex	NM_011077	0.72 ± 0.12a	0.67 ± 0.12a	0.58 ± 0.14a	0.0002
Osteoclast
Trap	NM_007388	0.68 ± 0.11a	0.63 ± 0.13a	0.36 ± 0.09a,b	<0.0001
Mmp9	NM_013599	0.95 ± 0.16	0.69 ± 0.08a	0.63 ± 0.07a	0.0001
Chondrocyte
Collagen II	NM_031163	0.99 ± 0.13	1.03 ± 0.26	1.13 ± 0.23	0.5764
VegfA	NM_009505	1.07 ± 0.26	1.06 ± 0.21	0.97 ± 0.31	0.8905
Adipocyte
PPARγ	NM_009505	1.08 ± 0.15	1.20 ± 0.19	1.40 ± 0.13a	0.0025
aP2	NM_024406	1.13 ± 0.16	1.55 ± 0.23a	1.95 ± 0.26a,b	<0.0001
Lpl	NM_008509	1.38 ± 0.25a	1.42 ± 0.27a	2.01 ± 0.29a,b	<0.0001
Others
IFNγ	NM_008337	2.42 ± 0.79a	2.70 ± 1.21a	3.57 ± 1.51a	0.0039
TNFα	NM_013693	1.18 ± 0.32	1.23 ± 0.69	1.13 ± 0.39	0.8371
TRAIL	NM_009425	1.36 ± 0.51	1.33 ± 0.48	1.29 ± 0.45	0.4500
Alox15	NM_009660	1.93 ± 0.38a	2.22 ± 0.89a	2.40 ± 0.95a	0.0106

^a Significant difference from control (Pkd1^flox/+) at p < 0.05.

^b Significant difference from single heterozygous Oc-Cre;Pkd1^flox/+ and Pkd1^flox/m1Bei mice at p < 0.05.