TABLE 2.
Biochemistry analysis of serum in 16-week-old mice
Data are mean ± S.D. from nine individual mice. Osteocalcin is produced by osteoblasts, and TRAP is produced by osteoclasts.
| Genotype | Pkd1flox/+ | Oc-Cre;Pkd1flox/+ | Pkd1flox/m1Bei | Oc-Cre;Pkd1flox/m1Bei |
|---|---|---|---|---|
| Serum urea nitrogen (mg/dl) | 19 ± 4.9 | 20 ± 4.8 | 22 ± 4.3 | 22 ± 5.2 |
| Calcium (mg/dl) | 8.9 ± 0.27 | 8.7 ± 0.38 | 8.6 ± 0.34 | 8.5 ± 0.37 |
| Phosphorus (mg/dl) | 8.3 ± 0.95 | 8.5 ± 1.17 | 8.6 ± 1.50 | 8.8 ± 0.76 |
| Osteocalcin (ng/ml) | 87 ± 21.3 | 74 ± 13.8a | 64 ± 18.6a | 56 ± 12.6a,b |
| TRAP (units/liter) | 12.6 ± 4.54 | 8.0 ± 2.94a | 6.5 ± 1.61a | 5.1 ± 0.94a,b |
a Significant difference from control (Pkd1flox/+) at p < 0.05.
b Significant difference from single heterozygous Oc-Cre;Pkd1flox/+ and Pkd1flox/m1Bei mice at p < 0.05.