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A, c-Jun and PDK1 levels increase in melanoma cell lines. Protein extracts (40 μg) from melanoma cell lines were analyzed by Western blots using the indicated antibodies. Human melanocytes served as controls. The cell lines WM115, WM793, and Lu1205 have deregulated PTEN. B, PDK1 levels are increased in melanoma tumor specimens and correlate with c-Jun levels. Protein samples (80 μg) obtained from melanoma tumors were analyzed by Western blot using the indicated antibodies.
