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Relationship between motility, metastasis, and the interaction of rNMMIIHCA with wild type and mutant S100A4 proteins. The equilibrium dissociation constants for the interaction of mutant S100A4 proteins and immobilized rNMMIIHCA were determined using an optical biosensor and plotted against the motility and metastasis-promoting properties of Rama 37 cells expressing wild type or mutant S100A4 proteins.
