Table 1.
Demographic, clinical and cognitive assessment information on each semantic dementia patient and healthy control participants
| Case 1 | Case 2 | Case 3 | Case 4 | Case 5 | Controls (n = 8) | |
|---|---|---|---|---|---|---|
| Demographic and clinical | ||||||
| Age (years) | 64 | 60 | 66 | 67 | 56 | 66.2 (12.5) |
| Sex | F | M | F | F | F | 6 F/2 M |
| Education | 16 | 12 | 13 | 16 | 14 | 18.2 (2.2)* |
| Handedness | R | R | L | R | R | 6 R/2 L |
| Years from first symptom | 8 | 7 | 7 | 6 | 3 | NA |
| General cognitive status | ||||||
| MMSE (30) | 22 | 17 | 26 | 29 | 27 | 29.6 (0.7)* |
| CDR total | 1 | 1 | 0.5 | 0.5 | 1 | 0.0 (0.0)* |
| Language | ||||||
| Phonemic fluency | 4 | 9 | 8 | 7 | 9 | 15.1 (3.1)* |
| Semantic fluency | 3 | 7 | 2 | 4 | 11 | 25.6 (5.5)* |
| Boston naming test (15) | 2 | 3 | 2 | 3 | 4 | 15 (NA)* |
| Speech fluency (WAB, 10) | 8 | 8 | 10 | 9 | 9 | 10 (NA) |
| Repetition (WAB, 100) | 88 | NA | 92 | 86 | 89 | NA |
| Apraxia of speech rating (7) | 0 | 3 | 0 | 0 | 0 | 0 |
| Dysarthria rating (7) | 0 | 3 | 0 | 0 | 0 | 0 |
| Word recognition (WAB, 60) | 51 | 51 | 56 | 58 | 57 | NA |
| Peabody picture vocabulary test (16) | 2 | 3 | 5 | 6 | 11 | 15.7 (0.7) |
| Sequential commands (WAB, 80) | 76 | NA | 76 | 72 | 80 | NA |
| Syntactic comprehension (CYCLE, 55) | 53 | 42 | 54 | 52 | 43 | NA |
| Pyramids and palm trees—Pictures (52) | 32 | 41 | 34 | 45 | 46 | NA |
| Reading | ||||||
| PALPA Regular words (30) | 24 | 28 | 20 | 29 | 30 | NA |
| PALPA Exception words (30) | 13 | 22 | 17 | 23 | 23 | NA |
| PALPA Pseudowords (24) | 37 | 50 | 37 | 52 | 53 | NA |
| Visuospatial function | ||||||
| Modified Rey–Osterrieth copy (17) | 17 | 12 | 15 | 14 | 16 | 15.6 (0.9) |
| VOSP | 10 | NA | 9 | 10 | 10 | 9.1 (1.3) |
| Visual memory | ||||||
| Modified Rey–Osterrieth delay (17) | 0 | 1 | 11 | 10 | 13 | 12.6 (3.2)* |
| Verbal memory | ||||||
| CVLT-MS Trials 1–4 | 7 | 4 | 16 | 14 | 20 | 30.0 (5.9)* |
| CVLT-MS 30 s free recall | 0 | 0 | 1 | 0 | 4 | 8.2 (1.3)* |
| CVLT-MS 10 min free recall | 0 | 1 | 0 | 0 | 4 | 7.6 (2.6)* |
| Executive | ||||||
| Digit span backwards | 6 | 3 | 4 | 5 | 4 | 4.7 (0.7) |
| Modified trails lines per minute | 11 | 23 | 24 | 49 | 42 | 40.0 (15.2) |
| Calculation | 5 | 4 | 5 | 5 | 4 | 4.7 (0.5) |
Controls’ scores are listed as means with SDs in parentheses. Asterisks indicate significantly different values from controls (P < 0.05).
F = female; M = male; R = right; L = left; CDR = Clinical Dementia Rating; WAB = Western Aphasia Battery; CYCLE = Curtiss-Yamada Comprehensive Language Examination; PALPA = psycholinguistic assessment of language processing in aphasia; VOSP = Visual Object and Space Perception Battery; CVLT-MS = California Verbal Learning Test-Mental Status.